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Nature of course request C01408 :

New course

Undergraduate

First term offered : Winter 2012
Course Prefix&Number	Descriptive Title	Credits/Hours
CH 322	Medicinal Chemistry and Pharmacology	4 - 0

Abbreviation for Class Schedule(20 spaces) Med Chem and Pharm

Catalog Description: This class surveys the general mechanisms underlying the effects of drug compounds on biological organ systems. Topic areas include: the investigation of different drug classes and their biological targets, the behavior of drugs within the body, drug discovery and design, and the principles of cardiovascular-, endocrine-, and neuro-pharmacology. Prerequisites: either CH 104, CH 105, and CH106 or CH 334 and BI 102 or BI 211 or consent of instructor.

Course Goal and Objectives: This course is designed for upper division undergraduate, medicinal chemistry, and nursing students that are interested to learn about how drug compounds affect biological systems. It is highly recommended for students that are interested in pursuing a graduate or professional degree in the medical sciences. By the end of the course, students should be able to: 1. Apply key biochemical principles to explain disease states and therapeutic strategies 2. Explain how drugs compounds affect mechanisms of enzyme action, cellular signaling and communication, cellular metabolism, and protein regulation. 3. Define the basic physiochemical properties that affect drug absorption, distribution, metabolism, excretion (ADME), and the impact of those properties on pharmacokinetics and pharmacodynamics. 4. Relate the structure of active metabolites to their biological function 5. Understand the process of drug discovery, design, testing, and marketing within the pharmaceutical industry 6. Gain familiarity with major classes of drug compounds and their pharmacological effects, including cardiovascular agents, anti-inflammatory and immune agents, antibiotic and anti-infective agents, and agents that affect the central and peripheral nervous system.

Justification for adding the course (e.g. alignment with other institutions, program revision, etc.): The purpose of adding the `Medicinal Chemistry and Pharmacology¿ course to the department of Chemistry curriculum is to provide specialized coursework to support the proposed Medicinal Chemistry Emphasis Program that is being submitted to the Curriculum Committee concurrently with this proposal. The course aligns with a primary mission statement of WOU, which is to teach a wide diversity of specialized courses in a personalized setting, and the overall objectives of the National Institutes of Health (NIH), to understand how the human body works and gain insight into countless diseases and disorders. This will enable a higher standard of training to both pre-professional healthcare-oriented students, and students that want to prepare for the rigors of graduate school. Finally, the course material is tailored to the educational and research expertise of Professor Flatt and can be taught without the addition of another faculty member.

Faculty and facilities needed: No additional faculty or facilities are required.

Brief Course outline: Week 1 ¿ Pharmacokinetics: Drug-Receptor Interactions Week 2 ¿ Pharmacokinetics: Drug Absorption, Distribution, Metabolism and Excretion Week 3 ¿ Anti-infective agents: Classes of antibiotics and their cellular targets Week 4 ¿ Anti-infective agents: Viruses, vaccines, and antiviral agents Week 5 ¿ Inflammatory response: Eicosinoids and Histamine Week 6 ¿ Immune pharmacology: Hematopoiesis and immunomodulation Week 7 ¿ Endocrine pharmacology: Reproductive processes and the estrogen receptor Week 8 ¿ Cholesterol and Lipoprotein metabolism Week 9 ¿ Cardiovascular function and pharmacology Week 10 ¿ Drug Discovery: Finding a lead, optimizing target interactions, and getting the drug to market.

Approval Queue C01408

Attached Files:

Proposed Syllabus for Med Chem and Pharm 1-9-11.docx

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