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Nature of course request C02602 :

New course

Undergraduate

First term offered : Winter 2015
Course Prefix&Number	Descriptive Title	Credits/Hours
CH 445	Toxicology Laboratory Techniques	3 -

Abbreviation for Class Schedule(20 spaces) CH 445 Tox Lab

Catalog Description: General biochemical and physical techniques used in toxicology are covered with an emphasis on model systems. The course covers laboratory techniques such as environmental analysis of pollutants and other toxicological components, dose response curves, morphological effects, drug testing and metabolism, genetic and epigenetic techniques, and molecular probes for evaluating DNA, RNA, and protein effects following xenobiotic exposure.

Course Goal and Objectives: This course is designed for upper division undergraduate students that are interested to learn about how toxic compounds affect biological systems. It is highly recommended for students that are interested in pursuing a graduate or professional degree in the forensic or medical sciences. By the end of the course, students should be able to: 1. Explain how toxic compounds are absorbed, distributed, and excreted from the human body. 2. Understand the types of exposure, routes of exposure and common metabolic pathways of xenobiotic compounds 3. Describe the structure of DNA and explain how it carries genetic information in its base sequence. 4. Describe how mutagenic substances can alter DNA structure and function leading to chemical carcinogenesis. 5. Explain how toxicants can alter gene expression and function 6. Understand the analytical and laboratory procedures utilized to study the effects of toxicants on biological systems.

Justification for adding the course (e.g. alignment with other institutions, program revision, etc.): The purpose of adding an `Toxicology Laboratory Techniques¿ course to the department of Chemistry curriculum is four-fold. First, the course aligns well with the Forensic Chemistry Major option by providing an elective course centered on a fundamental area of forensic investigation. This would broaden current forensic chemistry coursework to include hands-on training in toxicological laboratory skills. This would increase the ability of our current Forensic Degree option to meet the Forensic Science Education Programs Accreditation Commission (FEPAC) and Federal Bureau of Investigations (FBI) certification and training requirements. Secondly, the course aligns well with a primary objective of the National Institutes of Health (NIH), to understand how the human body works and gain insight into countless diseases and disorders. This will enable a higher standard of training to pre-professional healthcare-oriented students enrolled in the new Medicinal Chemistry and Pharmacology Emphasis Major option offered within the Chemistry department, lending to the success of students that want to pursue advanced degrees in professional or graduate programs. In addition, the coursework also aligns well with the new Environmental Chemistry Emphasis program and can be utilized as an upper division elective course for all of our Chemistry degree programs. Finally, the course material is tailored to the educational and research expertise of Professor Flatt and can be taught without the addition of another faculty member.

Faculty and facilities needed: The New DeVolder Family Science Center Facilities will be utilized for the new CH445 Toxicology Laboratory Techniques course offering. In addition, the course material is tailored to the educational and research expertise of Professor Flatt and can be taught without the addition of another faculty member. Thus, no new facilities or faculty are required for these program modifications.

Brief Course outline: 1 Introduction to toxicology ¿ types of toxic agents, dose-response curves, types of exposure 2 Evaluation of Environmental Contaminants and EPA Standards 3 Analysis of Superfund Sites and Waste Disposal 4 Effects of toxicological agents on biological systems 5 Biological probes analyzing effects of xenobiotic agents on DNA, RNA, protein and other major macromolecules. 6 Molecular toxicology ¿ alteration of gene expression and function 7 Examples of toxic agents ¿ radiation, heavy metals, organic substances 8 Drug metabolism and poisons 9 Forensic/diagnostic applications of toxicology and risk assessment

Approval Queue C02602

Attached Files:

CH445 Toxicology Syllabus.doc

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