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Back to Archive List

Nature of course request C00782 :

New course

Undergraduate

First term offered :
Course Prefix&Number	Descriptive Title	Credits/Hours
CH 345	Introduction to Toxicology	3 -

Abbreviation for Class Schedule(20 spaces) Intro to Toxicology

Catalog Description: This class surveys the general mechanisms underlying the effects of toxic compounds on biological systems. Topics that will be covered include: poisons and toxic agents, biotransformation of xenobiotics, reproductive toxicology and teratology, analytical/forensic toxicology, chemical carcinogenesis, and molecular toxicology. Prerequisites either CH 104, CH 105, and CH106 or CH 334 and BI 102 or BI 211 or consent of instructor.

Course Goal and Objectives: This course is designed for upper division undergraduate/nursing students that are interested to learn about how toxic compounds affect biological systems. It is highly recommended for students that are interested in pursuing a graduate or professional degree in the medical sciences. By the end of the course, students should be able to: 1. Explain how toxic compounds are absorbed, distributed, and excreted from the human body. 2. Understand the types of exposure, routes of exposure and common metabolic pathways of xenobiotic compounds 3. Describe the structure of DNA and explain how it carries genetic information in its base sequence. 4. Describe how mutagenic substances can alter DNA structure and function leading to chemical carcinogenesis. 5. Explain how toxicants can alter gene expression and function 6. Understand the analytical and laboratory procedures utilized to study the effects of toxicants on biological systems.

Justification for adding the course (e.g. alignment with other institutions, program revision, etc.): The purpose of adding an ¿Introduction to Toxicology¿ course to the department of Chemistry curriculum is four-fold. First, the course aligns well with the Forensic Chemistry Major option by providing an elective course centered on a fundamental area of forensic investigation. Current forensic-specific coursework does not cover this topic area in detail. Secondly, the newly established Nursing program between WOU and OHSU requires students to complete 12 elective credits. The Introduction to Toxicology Course will provide an additional upper division elective option related to the effects of chemical exposure on human health and should be of high interest to this population of students. Thirdly, the course aligns with a primary objective of the National Institutes of Health (NIH), to understand how the human body works and gain insight into countless diseases and disorders. This will enable a higher standard of training to both pre-professional healthcare-oriented students, and students that want to prepare for the rigors of graduate school. Finally, the course material is tailored to the educational and research expertise of Professor Flatt and can be taught without the addition of another faculty member.

Faculty and facilities needed: No additional faculty or facilities are required.

Brief Course outline: Week Topics 1 Introduction to toxicology ¿ types of toxic agents, dose-response curves, types of exposure 2 Absorption, distribution, and excretion of foreign substances 3 Bioactivation and metabolism of xenobiotics 4 Biomarkers and toxic responses 5 Effect of mutagens on DNA and the flow of genetic information 6 Chemical carcinogenesis 7 Molecular toxicology ¿ alteration of gene expression and function 8 Examples of toxic agents ¿ radiation, heavy metals, organic substances 9 Toxicological and analytical evalutation of complex environmental mixtures 10 Forensic/Diagnostic Application of toxicology and risk assessment

Approval Queue C00782

Attached Files:

Toxicology Syllabus.doc

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